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VU 0361737

CAS No. 1161205-04-4

VU 0361737( VU 0361737, VU-0361737, VU0361737 )

Catalog No. M17159 CAS No. 1161205-04-4

VU 0361737 is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 115 In Stock
50MG 191 In Stock
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Biological Information

  • Product Name
    VU 0361737
  • Note
    Research use only, not for human use.
  • Brief Description
    VU 0361737 is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors.
  • Description
    VU 0361737 is a selective positive allosteric modulator at mGluR-4 (EC50 values are 240 and 110 nM at human and rat receptors respectively).
  • In Vitro
    VU0361737 displays weak activity at mGlu5 and mGlu8 receptors and inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors.VU0361737 (1-10 μM) partially attenuates the Staurosporine (HY-15141)- and Doxorubicin (HY-15142)-evoked cell death on human neuroblastoma SH-SY5Y cells.
  • In Vivo
    VU0361737 exhibits terminal elimination half-lives (rat 1.9 h) due to high plasma clearance (894 mL/min/kg) following Intraperitoneal injection ( rat 10 mg/kg). Animal Model:Male Sprague-Dawley rats (225-250 g)Dosage:10 mg/kg (Pharmacokinetic Analysis)Administration:Intraperitoneal injection Result:T1/2 (1.9 h).
  • Synonyms
    VU 0361737, VU-0361737, VU0361737
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    mGluR4 (Human)| mGluR4 (Rat )
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    1161205-04-4
  • Formula Weight
    262.69
  • Molecular Formula
    C13H11ClN2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 43 mg/mL 163.69 mM
  • SMILES
    COc1c(ccc(c1)NC(=O)c1ccccn1)Cl
  • Chemical Name
    N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Engers DW, et al. J Med Chem, 2009, 52(14), 4115-4118.
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