
VU 0361737
CAS No. 1161205-04-4
VU 0361737( VU 0361737, VU-0361737, VU0361737 )
Catalog No. M17159 CAS No. 1161205-04-4
VU 0361737 is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 42 | In Stock |
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10MG | 60 | In Stock |
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25MG | 115 | In Stock |
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50MG | 191 | In Stock |
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100MG | 348 | In Stock |
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500MG | 807 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameVU 0361737
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NoteResearch use only, not for human use.
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Brief DescriptionVU 0361737 is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors.
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DescriptionVU 0361737 is a selective positive allosteric modulator at mGluR-4 (EC50 values are 240 and 110 nM at human and rat receptors respectively).
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In VitroVU0361737 displays weak activity at mGlu5 and mGlu8 receptors and inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors.VU0361737 (1-10 μM) partially attenuates the Staurosporine (HY-15141)- and Doxorubicin (HY-15142)-evoked cell death on human neuroblastoma SH-SY5Y cells.
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In VivoVU0361737 exhibits terminal elimination half-lives (rat 1.9 h) due to high plasma clearance (894 mL/min/kg) following Intraperitoneal injection ( rat 10 mg/kg). Animal Model:Male Sprague-Dawley rats (225-250 g)Dosage:10 mg/kg (Pharmacokinetic Analysis)Administration:Intraperitoneal injection Result:T1/2 (1.9 h).
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SynonymsVU 0361737, VU-0361737, VU0361737
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PathwayOthers
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TargetOther Targets
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RecptormGluR4 (Human)| mGluR4 (Rat )
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number1161205-04-4
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Formula Weight262.69
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Molecular FormulaC13H11ClN2O2
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 43 mg/mL 163.69 mM
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SMILESCOc1c(ccc(c1)NC(=O)c1ccccn1)Cl
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Chemical NameN-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Engers DW, et al. J Med Chem, 2009, 52(14), 4115-4118.
molnova catalog



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