VU 0361737

CAS No. 1161205-04-4

VU 0361737( VU 0361737, VU-0361737, VU0361737 )

Catalog No. M17159 CAS No. 1161205-04-4

VU 0361737 is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 42 In Stock
10MG 60 In Stock
25MG 115 In Stock
50MG 191 In Stock
100MG 348 In Stock
500MG 807 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    VU 0361737
  • Note
    Research use only, not for human use.
  • Brief Description
    VU 0361737 is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors.
  • Description
    VU 0361737 is a selective positive allosteric modulator at mGluR-4 (EC50 values are 240 and 110 nM at human and rat receptors respectively).
  • In Vitro
    VU0361737 displays weak activity at mGlu5 and mGlu8 receptors and inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors.VU0361737 (1-10 μM) partially attenuates the Staurosporine (HY-15141)- and Doxorubicin (HY-15142)-evoked cell death on human neuroblastoma SH-SY5Y cells.
  • In Vivo
    VU0361737 exhibits terminal elimination half-lives (rat 1.9 h) due to high plasma clearance (894 mL/min/kg) following Intraperitoneal injection ( rat 10 mg/kg). Animal Model:Male Sprague-Dawley rats (225-250 g)Dosage:10 mg/kg (Pharmacokinetic Analysis)Administration:Intraperitoneal injection Result:T1/2 (1.9 h).
  • Synonyms
    VU 0361737, VU-0361737, VU0361737
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    mGluR4 (Human)| mGluR4 (Rat )
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    1161205-04-4
  • Formula Weight
    262.69
  • Molecular Formula
    C13H11ClN2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 43 mg/mL 163.69 mM
  • SMILES
    COc1c(ccc(c1)NC(=O)c1ccccn1)Cl
  • Chemical Name
    N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Engers DW, et al. J Med Chem, 2009, 52(14), 4115-4118.
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